Benzo[a]pyrene exacerbates allergen-induced airway inflammation through NLRP3-dependent dendritic cell activation and pathogenic T helper cell polarization
BaP amplifies allergic airway disease by activating the NLRP3 inflammasome in DCs, thereby enhancing DC maturation, cytokine release, and pathogenic Th2/Th17 polarization. These findings identify a critical mechanism linking environmental pollutants to exacerbated allergic asthma and highlight the NLRP3 inflammasome as a potential therapeutic target.
Authors
- Aizhi Zhang
- Ping‐Chang Yang (ORCID: https://orcid.org/0000-0002-3650-0416)
- Y. Ye (ORCID: https://orcid.org/0000-0002-4960-3377)
- Gui Yang (ORCID: https://orcid.org/0000-0002-5413-0121)
- Jiaqi Duan
- Yongmin Xie
- Ruien Chen
- Huamei Zou
- Xiaoyu Liu (ORCID: https://orcid.org/0009-0006-6681-2783)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shanxi Medical University (CN)
- Shenzhen University (CN)
- Longgang Central Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1699886
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- State Key Laboratory of Respiratory Disease
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Shenzhen University