Case report of immune checkpoint inhibitor induced cholestatic hepatitis, acute renal injury and asymptomatic pancreatic enzyme elevation simultaneously
Immunosuppression by standard glucocorticoid showed limited efficacy in cholestatic hepatitis. The 2 patients received artificial liver support improved biochemically, while bilirubin adsorption alone provided only transient reduction of bilirubin in one case. As for final clinical outcome, one patient died from severe infection during therapy agianst irAE; one patient died from cancer progression despite irAE recovery; and the others achieved full recovery from this irAE combination.
Authors
- Muwen Nie (ORCID: https://orcid.org/0009-0009-4992-0303)
- Chunmei Bai
- Hongyan Ying
- Na Zhou (ORCID: https://orcid.org/0000-0003-2656-7948)
- Chen-Yu Wang (ORCID: https://orcid.org/0000-0002-6716-0565)
- Yuan Liu (ORCID: https://orcid.org/0000-0003-2030-1153)
- Zhiyang Zhang (ORCID: https://orcid.org/0000-0002-2930-5575)
- Jing Leng (ORCID: https://orcid.org/0000-0001-6115-2153)
- Rui Jiao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1679328
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Peking Union Medical College Hospital