Neutrophils, not macrophages, aid phage-mediated control of pulmonary Pseudomonas aeruginosa infection
Since neutrophils play a key-role in supporting phage-mediated <i>Pseudomonas</i> clearance, the efficacy of phage therapy is closely linked to the hosts immune competence - an important consideration when treating immunocompromised patients.
Authors
- Katharina Ahrens (ORCID: https://orcid.org/0000-0002-6621-6379)
- Shailey Twamley (ORCID: https://orcid.org/0000-0002-1607-6574)
- Jean-Damien Ricard (ORCID: https://orcid.org/0000-0003-1828-2299)
- Geraldine Nouailles (ORCID: https://orcid.org/0000-0003-1973-3119)
- Ulrike Behrendt
- Chantal Weissfuss (ORCID: https://orcid.org/0000-0003-3701-3190)
- Magdalena Bürkle (ORCID: https://orcid.org/0000-0002-4767-2942)
- Laurent Debarbieux (ORCID: https://orcid.org/0000-0001-6875-5758)
- Christine H. Rohde (ORCID: https://orcid.org/0000-0001-9005-7753)
- Imke H. E. Korf (ORCID: https://orcid.org/0000-0001-6073-9307)
- Christian Zobel (ORCID: https://orcid.org/0000-0002-6358-1215)
- Karen Hoffmann (ORCID: https://orcid.org/0000-0002-1528-6617)
- Martin Witzenrath
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Humboldt-Universität zu Berlin (DE)
- Hôpital Louis-Mourier (FR)
- Ecologie & Evolution (FR)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- German Center for Lung Research (DE)
- Bundeswehrkrankenhaus Ulm (DE)
- Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1681461
- Citations
- 2
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- Gentofte Hospital
- Rigshospitalet