Ivabradine, atrial fibrillation and stroke: a combined meta-analysis and FAERS disproportionality analysis
Our findings raise the hypothesis that ivabradine facilitates an increased diagnosis rather than playing a direct role in causing AF. Prospective studies with continuous ECG monitoring and standardized endpoints are needed to clarify the temporal and mechanistic relationship between ivabradine, AF recognition, and cerebrovascular risk.
Authors
- Giulia Massaro (ORCID: https://orcid.org/0000-0002-1227-5787)
- Martina Amadori
- Elena Nardi (ORCID: https://orcid.org/0000-0003-4245-912X)
- Alberto Spadotto (ORCID: https://orcid.org/0000-0001-8452-7405)
- Milo Gatti (ORCID: https://orcid.org/0000-0003-3018-3779)
- Michele Fusaroli (ORCID: https://orcid.org/0000-0002-0254-2212)
- Elisabetta Poluzzi (ORCID: https://orcid.org/0000-0002-7209-0426)
- Emanuel Raschi (ORCID: https://orcid.org/0000-0003-0487-7996)
- Maria Carelli (ORCID: https://orcid.org/0000-0001-5518-6226)
- Igor Diemberger
- Veronica De Angelis
- V Ciubine
Institutions
- Azienda USL di Bologna (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fphar.2025.1638923
- Primary Topic
- Heart rate and cardiovascular health
- Type
- article
- Field-Weighted Citation Impact
- 0.00