Protective effects of Angelica sinensis polysaccharide on chemotherapy-injured rats with premature ovarian insufficiency and its impact on gut microbiota
ASP ameliorates chemotherapy-induced POI in rats by improving the serum hormone levels, promoting follicular development, as well as suppressing inflammation and oxidative stress, with medium and high treatment doses showing significant efficacies. Furthermore, ASP reshapes the gut microbiome; the altered gut microbiota are strongly correlated with ovarian function indicators, suggesting that they may serve as a new therapeutic approach for POI.
Authors
- Maoyuan Wu
- Xiaoling Jiang (ORCID: https://orcid.org/0000-0001-6004-0176)
- Lianli He (ORCID: https://orcid.org/0000-0001-6644-0293)
- Min Wang (ORCID: https://orcid.org/0000-0002-1288-016X)
- Lixia Zhang (ORCID: https://orcid.org/0000-0002-2689-2452)
- Xuemei Chen (ORCID: https://orcid.org/0000-0002-5209-1157)
- Hong Shu (ORCID: https://orcid.org/0000-0002-2844-8347)
- Yan Xu (ORCID: https://orcid.org/0000-0001-9602-7328)
Institutions
- Zunyi Medical University (CN)
- First People’s Hospital of Zunyi (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fphar.2025.1685281
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00