Health risks of cocaine adulteration: local anesthetics as modulators of monoamine and organic cation transporters
Although LAs modulate uptake-1 and uptake-2 transporters, their actions are insufficient to replicate cocaine's psychoactive effects. However, their impact on OCTs indicates potential health risks, highlighting the importance of accessible drug checking services for harm reduction.
Authors
- Anton Luf (ORCID: https://orcid.org/0000-0003-4013-7135)
- Alexandra Karden
- Thomas Stockner (ORCID: https://orcid.org/0000-0002-7071-8283)
- Marion Holy
- Oliver Kudlacek (ORCID: https://orcid.org/0000-0002-3086-8551)
- Harald H. Sitte (ORCID: https://orcid.org/0000-0002-1339-7444)
- Fatemeh Kooti
- Iina Ludwig
- Julia Bicher
- Niklas Senning
Institutions
- Al-Ahliyya Amman University (JO)
- TU Wien (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fphar.2025.1699035
- Primary Topic
- Forensic Toxicology and Drug Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund