R3HDM4 influences kidney renal clear cell carcinoma progression, immune modulation, and potential links to the IGSF8 immune checkpoint
These analyses identify R3HDM4 as a critical oncogenic driver in KIRC, potentially acting through two mechanisms: promoting tumor growth and metastasis while also exerting immunomodulatory effects, possibly mediated by IGSF8. This suggests a potential role for IGSF8 in regulating immune checkpoints, though this remains speculative. These findings highlight R3HDM4's potential as both a prognostic biomarker and a therapeutic target in KIRC.
Authors
- Song Wen (ORCID: https://orcid.org/0000-0001-6173-0507)
- Kai Sun (ORCID: https://orcid.org/0000-0001-9619-9007)
- Kongjia Wang (ORCID: https://orcid.org/0009-0002-0995-409X)
- Rong Li (ORCID: https://orcid.org/0000-0002-8210-1213)
- Dechang Xu
- Ting Xu (ORCID: https://orcid.org/0000-0002-0172-9683)
Institutions
- Ganzhou People's Hospital (CN)
- Gannan Medical University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1722358
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00