Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection
The systemic immune dysregulation observed in PJI patients can lay the foundation for further in-depth understanding of the immune response in PJI. The immune-related markers demonstrated promising value in diagnosing PJI, especially when synovial fluid was unavailable. Multicenter validation was warranted to confirm clinical utility.
Authors
- Libo Hao (ORCID: https://orcid.org/0000-0003-3052-8714)
- Jun Fu (ORCID: https://orcid.org/0000-0002-8723-1439)
- Zhiyuan Li (ORCID: https://orcid.org/0000-0003-3052-1109)
- Zhuo Li (ORCID: https://orcid.org/0000-0002-9296-2738)
- Jiying Chen (ORCID: https://orcid.org/0000-0003-1377-4825)
- Lin Yuan
- Fan Yang (ORCID: https://orcid.org/0000-0003-0387-9682)
- Chi Xu
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1648150
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00