Integrated multi-omics reveals GABARAP-mediated mitophagy and pyruvate metabolism as key drivers of osteosarcoma progression
These findings reveal that GABARAP links mitophagy-driven metabolic adaptation with immune evasion, representing a key regulator and potential therapeutic target in osteosarcoma.
Authors
- Guowen Wang (ORCID: https://orcid.org/0000-0003-0945-7579)
- Tingfang Li (ORCID: https://orcid.org/0009-0008-6324-9993)
- Jinyan Feng (ORCID: https://orcid.org/0000-0002-5334-5067)
- Yiqin Li (ORCID: https://orcid.org/0000-0001-8900-5198)
- Feng Wang (ORCID: https://orcid.org/0000-0003-4073-7181)
- Qingchen Zhang (ORCID: https://orcid.org/0000-0003-4981-6732)
- Xiuxin Han (ORCID: https://orcid.org/0000-0001-6745-8794)
- Yongheng Liu (ORCID: https://orcid.org/0000-0003-4314-0065)
Institutions
- Nankai University (CN)
- National Medical Products Administration (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tianjin International Joint Academy of Biomedicine (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1680554
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College