Beyond the skin: immunological profiles and infectious complications in ALOX12B-associated autosomal recessive congenital ichthyosis
Our findings suggest that ALOX12B-related ARCI may involve secondary immune dysregulation, driven by chronic compromise of the epidermal barrier. An immunologic evaluation is warranted in selected cases, particularly those with a history of susceptibility to infections. Multidisciplinary care, encompassing dermatology, immunology, and genetics, is crucial for achieving optimal outcomes in ARCI.
Authors
- Safa Barış (ORCID: https://orcid.org/0000-0002-4730-9422)
- Oğuz Salih Dinçer (ORCID: https://orcid.org/0000-0003-0407-5635)
- Elif Karakoç-Aydıner (ORCID: https://orcid.org/0000-0003-4150-5200)
- Leyla Baykal Selçuk (ORCID: https://orcid.org/0000-0001-7956-4033)
- Baran Erman (ORCID: https://orcid.org/0000-0001-9398-8465)
- Klaus Schmitz‐Abe (ORCID: https://orcid.org/0000-0002-7242-8861)
- Mehdi Benamar (ORCID: https://orcid.org/0000-0003-1532-8642)
- Asena Pınar Sefer (ORCID: https://orcid.org/0000-0003-2667-0291)
- Talal A. Chatila (ORCID: https://orcid.org/0000-0001-7439-2762)
- Mehmet Cihangir Çatak (ORCID: https://orcid.org/0000-0002-1387-5653)
- Ahmet Özen
- Pankaj B. Agrawal (ORCID: https://orcid.org/0000-0003-3255-0456)
- Sevgi Bilgiç Eltan (ORCID: https://orcid.org/0000-0003-0561-3343)
- Feven Getachew
- İsa An (ORCID: https://orcid.org/0000-0003-3366-4551)
- Feyza Bayram Catak
- Necmiye Öztürk
Institutions
- Boston Children's Hospital (US)
- Recep Tayyip Erdoğan University (TR)
- Karadeniz Technical University (TR)
- Jackson Health System (US)
- University of Miami Hospital (US)
- Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi (TR)
- Center for Translational Molecular Medicine (NL)
- Jeffrey Modell Foundation (AU)
- Hacettepe University (TR)
- Marmara University (TR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1662858
- Primary Topic
- Skin and Cellular Biology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00