Optimization of concentration-directed blood purification therapy in the management of diquat poisoning

Diquat, a non-selective herbicide extensively used in China, is characterized by moderate toxicity and the absence of a specific antidote. Acute diquat poisoning frequently leads to multiple organ dysfunction syndrome (MODS), posing significant clinical challenges. This study investigated the application and optimization of concentration-directed blood purification therapy in patients suffering from diquat poisoning complicated by MODS. We analyzed the clinical outcomes of four patients who underwent hemodialysis, hemoperfusion (HP), and other blood purification modalities. The results demonstrated that individualized treatment regimens-guided by real-time monitoring of plasma diquat concentrations-markedly enhanced therapeutic efficacy and improved patient prognoses. By dynamically tailoring blood purification protocols to the patients' toxin levels, this study introduced a novel clinical intervention strategy for the management of acute diquat poisoning. These findings underscore the clinical value of concentration-guided blood purification therapy and offer important insights for its broader implementation in practice.