Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis
Our lipid-based model effectively predicts septic shock and mortality, particularly in elderly sepsis patients. Age-associated lipid alterations (PC, LPC, CE reduction) correlate with disease severity and immune dysregulation, suggesting distinct lipid-immune mechanisms in younger vs. elderly patients. These findings support lipidomics as a tool for sepsis risk stratification and personalized therapy.
Authors
- Ke Lin (ORCID: https://orcid.org/0000-0001-7223-1287)
- Peng Cui (ORCID: https://orcid.org/0000-0002-4566-6223)
- Ruiwen Sun
- Yanmin Wan (ORCID: https://orcid.org/0000-0001-5027-9423)
- Jingjing Zhao
- Sen Wang (ORCID: https://orcid.org/0000-0002-8325-6348)
- Ling Wang (ORCID: https://orcid.org/0000-0001-9292-8989)
- Xiaoyang Cheng
- Jing Wu
- Yuhan Sun (ORCID: https://orcid.org/0009-0000-4441-4828)
- Jingwen Ai
- Jialin Jin
Institutions
- SAIC-GM (China) (CN)
- Huashan Hospital (CN)
- Institute of Infection and Immunity (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1659425
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- Shanghai Hospital Development Center
- National Key Research and Development Program of China