Splenectomy modulates intrarenal B cell differentiation and impairs repair of post-ischemic kidney
Splenectomy exacerbates tubular damage and fibrosis during the repair phase of severe IRI and significantly alters the immunological microenvironment of the kidneys, promoting B cell differentiation. Our study suggests that splenectomy may worsen outcomes in IRI, and further studies investigating potential reparative pathways through the kidney-spleen axis are warranted.
Authors
- Wooseong Huh (ORCID: https://orcid.org/0000-0001-8174-5028)
- Hojin Jeon (ORCID: https://orcid.org/0000-0002-2619-1736)
- Junseok Jeon
- Jung Eun Lee
- Kyung Ho Lee (ORCID: https://orcid.org/0000-0002-0108-3376)
- Hye Ryoun Jang
- Ghee Young Kwon
- Kyung Sub Lee
Institutions
- Samsung (South Korea) (KR)
- Samsung Medical Center (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1684731
- Primary Topic
- Renal and Vascular Pathologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00