Comprehensive analysis of the role of diverse programmed cell death patterns in sepsis
By integrating public microarray and single-cell transcriptomic data with independent high-throughput sequencing validation, this study analysis identifies ferroptosis, disulfidptosis, netotic death, and entotic death as key dysregulated PCD pathways in sepsis, with monocytes serving as central hubs integrating PCD, metabolic reprogramming, and immune communication. The CDS risk score provides a robust diagnostic and stratification tool. Targeting monocyte-driven PCD-metabolism-communication networks offers promising avenues for precision immunotherapy in sepsis.
Authors
- Shuo Sun (ORCID: https://orcid.org/0000-0003-3812-583X)
- Xue‐Zhong Yu (ORCID: https://orcid.org/0000-0002-1751-2884)
- Albert Yick Hou Lim (ORCID: https://orcid.org/0000-0003-4917-8144)
- Xiaonan Wang (ORCID: https://orcid.org/0000-0002-2342-4805)
- Chunyu Zhao (ORCID: https://orcid.org/0000-0001-9589-2416)
- Jing Ma (ORCID: https://orcid.org/0000-0001-6294-227X)
- Zihao Zhou (ORCID: https://orcid.org/0009-0001-4124-4664)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Jining Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1685533
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00