Molecular docking and pharmacological investigations of folenolide for its analgesic, anti-inflammatory, and antipyretic applications
Folenolide exhibits strong analgesic, anti-inflammatory, and antipyretic activities with a favorable safety profile. Its pharmacodynamic effects are supported by its molecular interactions with cyclooxygenase (COX), opioids, and histamine receptor targets. These findings highlight its potential as a promising therapeutic agent for pain, inflammation, and fever management.
Authors
- Asif Jan (ORCID: https://orcid.org/0000-0003-3880-5579)
- Faryal Ali
- Syed Shaukat Ali
- Fazli Khuda (ORCID: https://orcid.org/0000-0002-6847-1744)
- Muhammad Asif Khan (ORCID: https://orcid.org/0000-0002-3572-3001)
- Asmat Ullah (ORCID: https://orcid.org/0000-0002-5715-3425)
- Abdur Rasheed
- Atif Ali Khan Khalil (ORCID: https://orcid.org/0000-0003-1450-5635)
Institutions
- Sarhad University of Science and Information Technology (PK)
- Saidu Teaching Hospital (PK)
- King Saud University (SA)
- Jalalabad State University (KG)
- Nangarhar University (AF)
- University of Peshawar (PK)
- Yeungnam University (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fphar.2025.1658610
- Primary Topic
- Pomegranate: compositions and health benefits
- Type
- article
- Field-Weighted Citation Impact
- 0.00