Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period

This study goes to reinforce the need for vaccination as though, all participants elicited a response towards endemic coronaviruses before the COVID-19 pandemic, a very small fraction of participants had binding antibodies which cross-react with SARS-CoV-2 and none of these were neutralizing. Anti-SARS-CoV-2 antibodies from the studied pregnant Cameroonian women at delivery during the pandemic had neutralizing activity against the founder variant and were efficiently transferred to the newborn. However the neutralization against other variants of concern warrants future investigation.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-11-19
DOI
https://doi.org/10.3389/fimmu.2025.1628102
Primary Topic
COVID-19 Impact on Reproduction
Type
article
Field-Weighted Citation Impact
0.00

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article

Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period

Eitel Mpoudi Ngolle, Reine Medouen Ndeumou Seumko’o, Tandile Hermanus, Penny L. Moore et al.
Frontiers in Immunology
COVID-19 Impact on Reproduction
article

Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period

Eitel Mpoudi Ngolle, Reine Medouen Ndeumou Seumko’o, Tandile Hermanus, Penny L. Moore, Rose G. F. Leke, Bernard Marie Zambo Bitye, Rosette Megnekou, Chris Marco Mbianda Nana, Diane Wallace Taylor, Thandeka Moyo-Gwete, Livo Forgu Esemu, Bodin Darcisse Kwanou Tchakounté, Romeo Djounda, Sosthene Hillary Matabou Tene, Tekougang Berenice Kenfack Zangue
article en

Abstract

This study goes to reinforce the need for vaccination as though, all participants elicited a response towards endemic coronaviruses before the COVID-19 pandemic, a very small fraction of participants had binding antibodies which cross-react with SARS-CoV-2 and none of these were neutralizing. Anti-SARS-CoV-2 antibodies from the studied pregnant Cameroonian women at delivery during the pandemic had neutralizing activity against the founder variant and were efficiently transferred to the newborn. However the neutralization against other variants of concern warrants future investigation.

Frontiers in ImmunologyVol. 16
National Health Laboratory Service (ZA), University of Hawaiʻi at Mānoa (US), Université de Yaoundé I (CM), University of Buea (CM), University of the Witwatersrand (ZA), Centre for the AIDS Programme of Research in South Africa (ZA), Centre Pasteur du Cameroun (CM), Ministry of Scientific Research and Innovation (CM), Institut de Recherches Médicales et d’Etudes des Plantes Médicinales (CM)
National Institute of Allergy and Infectious Diseases
Openalex Percentile: Top 55%
COVID-19 Impact on Reproduction
DOIOpen Access PDFOpenAlex
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