The potential mechanism of celastrol attenuating atherosclerosis by promoting macrophage autophagy via AMPK/ULK1 pathway
Cel exerts anti-atherosclerotic effects by activating macrophage autophagy via the AMPK/ULK1 pathway, thereby improving lipid metabolism, reducing inflammation, and stabilizing plaques. These findings highlight the therapeutic potential of Cel and provide new insights into autophagy-targeted strategies against AS.
Authors
- Ya‐Fang Chen (ORCID: https://orcid.org/0000-0003-2995-9189)
- Yanrong Zhao (ORCID: https://orcid.org/0000-0003-0539-6852)
- Yanfang Qi
- Linlin Fang (ORCID: https://orcid.org/0000-0001-7332-4186)
- Liping Wei (ORCID: https://orcid.org/0000-0001-6076-078X)
- Yue Liu (ORCID: https://orcid.org/0000-0002-9653-3551)
- Zhiguang Zhou
- Li Jiao (ORCID: https://orcid.org/0000-0002-0237-0262)
- Qi Li (ORCID: https://orcid.org/0000-0002-7835-5886)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- County Hospital (GB)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fphar.2025.1700663
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00