Development of a prognostic model based on immunogenic cell death/ferroptosis-related genes and the study of TREX1 effects on prostate cancer cells

The three-gene IFRG-based prognostic model may serve as a promising prognostic biomarker for PCa, providing predictive value and novel insights into the complex interactions between IFRGs and PCa progression. Moreover, TREX1 was identified as a potential therapeutic target, offering new perspectives for prognostic assessment and the development of immunotherapy strategies in PCa.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-11-19
DOI
https://doi.org/10.3389/fimmu.2025.1708437
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Development of a prognostic model based on immunogenic cell death/ferroptosis-related genes and the study of TREX1 effects on prostate cancer cells

J Yang, Dong Chen, Shaoxing Zhu, Jianhui Chen et al.
Frontiers in Immunology
Ferroptosis and cancer prognosis
article

Development of a prognostic model based on immunogenic cell death/ferroptosis-related genes and the study of TREX1 effects on prostate cancer cells

J Yang, Dong Chen, Shaoxing Zhu, Jianhui Chen, Song Zheng, Yaoan Wen, Shuyuan Zhan
article en

Abstract

The three-gene IFRG-based prognostic model may serve as a promising prognostic biomarker for PCa, providing predictive value and novel insights into the complex interactions between IFRGs and PCa progression. Moreover, TREX1 was identified as a potential therapeutic target, offering new perspectives for prognostic assessment and the development of immunotherapy strategies in PCa.

Frontiers in ImmunologyVol. 16
Fujian Medical University (CN), Fujian Provincial Hospital (CN), Union Hospital (CN)
Openalex Percentile: Top 49%
Ferroptosis and cancer prognosis
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