Development of a prognostic model based on immunogenic cell death/ferroptosis-related genes and the study of TREX1 effects on prostate cancer cells
The three-gene IFRG-based prognostic model may serve as a promising prognostic biomarker for PCa, providing predictive value and novel insights into the complex interactions between IFRGs and PCa progression. Moreover, TREX1 was identified as a potential therapeutic target, offering new perspectives for prognostic assessment and the development of immunotherapy strategies in PCa.
Authors
- J Yang
- Dong Chen (ORCID: https://orcid.org/0000-0003-3892-9248)
- Shaoxing Zhu
- Jianhui Chen (ORCID: https://orcid.org/0000-0002-7757-6089)
- Song Zheng
- Yaoan Wen (ORCID: https://orcid.org/0000-0002-3521-3837)
- Shuyuan Zhan
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1708437
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00