Atypical juxtaglomerular cell tumor in a young male with resistant hypertension and normal renin–aldosterone levels
Juxtaglomerular cell tumor (JGCT), or reninoma, is a rare renin-secreting renal neoplasm that typically presents with severe hypertension, hypokalemia, and elevated renin and aldosterone levels. We describe an atypical case of a 21-year-old male with morbid obesity and resistant hypertension who exhibited normal biochemical findings despite the presence of a renal mass. He underwent partial nephrectomy, resulting in immediate normalization of blood pressure and subsequent regression of left ventricular hypertrophy. This case underscores the importance of considering JGCT in patients with refractory hypertension and a renal mass, even when the characteristic biochemical profile is absent.
Authors
- Peyman Mohammadi Torbati (ORCID: https://orcid.org/0000-0002-7495-6764)
- Mohammad Sajjad Zabihi (ORCID: https://orcid.org/0000-0001-5643-1617)
- Emadoddin Hosseinjani (ORCID: https://orcid.org/0000-0002-1560-1939)
- Mohammadreza Kamranmanesh (ORCID: https://orcid.org/0000-0003-1853-5647)
- Mehdi Dadpour (ORCID: https://orcid.org/0000-0003-3550-3778)
- Nooshin Ahmadi (ORCID: https://orcid.org/0000-0002-2835-050X)
- Reza Paeizi
- Sepideh Besharati (ORCID: https://orcid.org/0000-0003-3200-1895)
- Nizar H. Saeedi (ORCID: https://orcid.org/0000-0002-9281-1550)
Institutions
- Golestan University (IR)
- Research Institute for Endocrine Sciences (IR)
- Golestan University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Urology Case Reports
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.eucr.2025.103280
- Primary Topic
- Cardiac tumors and thrombi
- Type
- article
- Field-Weighted Citation Impact
- 0.00