Study on the mechanism of Sangbaipi Decoction in treating acute lung injury via the inflammasome NLRP3 signaling pathway
This study investigated the pharmacodynamics and mechanism of SBPD in treating respiratory inflammation. SBPD protected mice against LPS-induced ALI by alleviating lung tissue damage. Through integrated investigation of the complete formulation and the monomer baicalin, it was collaboratively demonstrated that SBPD exerts anti-inflammatory effects via the NLRP3 inflammasome pathway.
Authors
- Huiwei Bao (ORCID: https://orcid.org/0000-0002-5787-1814)
- Baojun Xu (ORCID: https://orcid.org/0000-0003-0739-3735)
- Yuejie Wang (ORCID: https://orcid.org/0000-0003-0422-8072)
- Siyu Chen (ORCID: https://orcid.org/0000-0001-5745-5071)
- Xiaoya Wang (ORCID: https://orcid.org/0000-0003-4976-2420)
- Yang Xu (ORCID: https://orcid.org/0000-0003-2324-1299)
- Lijing Li (ORCID: https://orcid.org/0000-0002-9469-1644)
- Xinjie Zhang (ORCID: https://orcid.org/0009-0006-0476-1933)
Institutions
- BaiCheng Normal University (CN)
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jep.2025.120908
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00