In vitro two stage one compartment dumping test data and absorption/formulation PBBM modeling to explain a bioequivalence failure of valsartan formulations
The study demonstrated that a simple dynamic dissolution methodology can effectively predict in vivo bioequivalence and formulation performance. The application of the "dumping test" provided valuable insights into the dissolution characteristics of different formulations, highlighting its potential as a cost-effective and practical tool for biopredictive studies.
Authors
- Isabel González‐Álvarez (ORCID: https://orcid.org/0000-0002-1685-142X)
- Marival Bermejo (ORCID: https://orcid.org/0000-0001-5022-0544)
- Marta González‐Álvarez (ORCID: https://orcid.org/0000-0002-8122-1504)
- Alejandro Ruiz-Picazo (ORCID: https://orcid.org/0000-0003-1281-8208)
- Bárbara Sánchez-Dengra (ORCID: https://orcid.org/0000-0003-2159-4314)
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
Publication Details
- Journal
- European Journal of Pharmaceutics and Biopharmaceutics
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ejpb.2025.114932
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00