GMP-compliant manufacturing of allogeneic peripheral blood CAR-NK cells for the treatment of acute myeloid leukemia

This standardized, GMP-compliant protocol provides a robust platform for producing PB-derived CAR-NK cell therapies in a closed platform, advancing their clinical translation.

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Publication Details

Journal
Cytotherapy
Published
2025-11-20
DOI
https://doi.org/10.1016/j.jcyt.2025.07.009
Primary Topic
Immune Cell Function and Interaction
Type
article
Field-Weighted Citation Impact
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article

GMP-compliant manufacturing of allogeneic peripheral blood CAR-NK cells for the treatment of acute myeloid leukemia

Dean A. Lee, Laura Sánchez-Vega, Almudena García-Ortiz, Josep M. Canals et al.
Cytotherapy
Immune Cell Function and Interaction
article

GMP-compliant manufacturing of allogeneic peripheral blood CAR-NK cells for the treatment of acute myeloid leukemia

Dean A. Lee, Laura Sánchez-Vega, Almudena García-Ortiz, Josep M. Canals, Joaquín Martínez‐López, Daniel J. Powell, Paula Rı́o, Sara López‐García, Unai Perpiñá, María Liz Paciello, Alejandra Ortiz-Ruiz, Alejandra Leivas, Daniel Gil-Alós, Eva Castellano, Adrián Fernández, Raquel Oliva, Antonio Valeri, Rafael Alonso, Laura Córdoba-Espejo, Diana Sanjurjo, del Moral Patricia
article en

Abstract

This standardized, GMP-compliant protocol provides a robust platform for producing PB-derived CAR-NK cell therapies in a closed platform, advancing their clinical translation.

CytotherapyVol. 28(2)
Nationwide Children's Hospital (US), Research Institute Hospital 12 de Octubre (ES), Hospital Universitario 12 De Octubre (ES), Parker Institute for Cancer Immunotherapy (US), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (ES), Universidad Autónoma de Madrid (ES), University of Pennsylvania (US)
Openalex Percentile: Top 62%
Immune Cell Function and Interaction
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