GMP-compliant manufacturing of allogeneic peripheral blood CAR-NK cells for the treatment of acute myeloid leukemia
This standardized, GMP-compliant protocol provides a robust platform for producing PB-derived CAR-NK cell therapies in a closed platform, advancing their clinical translation.
Authors
- Dean A. Lee (ORCID: https://orcid.org/0000-0001-6693-5392)
- Laura Sánchez-Vega (ORCID: https://orcid.org/0000-0001-8930-7460)
- Almudena García-Ortiz (ORCID: https://orcid.org/0000-0002-5345-7990)
- Josep M. Canals (ORCID: https://orcid.org/0000-0001-6829-7670)
- Joaquín Martínez‐López (ORCID: https://orcid.org/0000-0001-7908-0063)
- Daniel J. Powell (ORCID: https://orcid.org/0000-0002-5966-8908)
- Paula Rı́o (ORCID: https://orcid.org/0000-0002-5424-5543)
- Sara López‐García (ORCID: https://orcid.org/0000-0002-7888-8850)
- Unai Perpiñá (ORCID: https://orcid.org/0000-0001-6694-1119)
- María Liz Paciello (ORCID: https://orcid.org/0000-0003-1798-8644)
- Alejandra Ortiz-Ruiz (ORCID: https://orcid.org/0000-0003-4059-8839)
- Alejandra Leivas (ORCID: https://orcid.org/0000-0002-3950-9002)
- Daniel Gil-Alós (ORCID: https://orcid.org/0009-0002-8504-2842)
- Eva Castellano (ORCID: https://orcid.org/0000-0003-0858-914X)
- Adrián Fernández (ORCID: https://orcid.org/0000-0003-0697-188X)
- Raquel Oliva (ORCID: https://orcid.org/0000-0002-0723-2993)
- Antonio Valeri (ORCID: https://orcid.org/0000-0002-7245-6977)
- Rafael Alonso
- Laura Córdoba-Espejo
- Diana Sanjurjo
- del Moral Patricia
Institutions
- Nationwide Children's Hospital (US)
- Research Institute Hospital 12 de Octubre (ES)
- Hospital Universitario 12 De Octubre (ES)
- Parker Institute for Cancer Immunotherapy (US)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (ES)
- Universidad Autónoma de Madrid (ES)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cytotherapy
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jcyt.2025.07.009
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00