Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal
By integrating spatial multi-omics with rational nanocarrier design, we designed a glutamine-functionalized liposomal system that exploits ASCT2 overexpression for tumor-selective accumulation of LND. Our findings revealed that this nanoagonist achieves significant CC suppression and chemoresistance reversal.
Authors
- Ayshamgul Hasim
- Liangliang Dai (ORCID: https://orcid.org/0000-0002-2041-9357)
- Jinqiu Li (ORCID: https://orcid.org/0000-0002-0134-7810)
- Xiaojiao Li (ORCID: https://orcid.org/0000-0002-0662-2850)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Yufeng Liu (ORCID: https://orcid.org/0000-0001-7154-963X)
- Jia Ma (ORCID: https://orcid.org/0000-0001-9236-2364)
- Xiaoyu Zhao (ORCID: https://orcid.org/0000-0001-5095-7212)
- Kefeng Li (ORCID: https://orcid.org/0000-0002-7233-4347)
- Xing Qin (ORCID: https://orcid.org/0009-0001-8809-2071)
Institutions
- Xinjiang Medical University (CN)
- Northwestern Polytechnical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
- Shaanxi Normal University (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.035
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00