Significance of SUMOylation in breast cancer progression: a comprehensive investigation using single-cell analysis and bioinformatics
Our findings reveal that SUMOylation subtypes in breast cancer exhibit distinct prognostic, immunological and pharmacogenomic profiles. These insights may provide candidate biomarkers for future personalized treatment strategies for breast cancer and potentially for other malignancies.
Authors
- Zhengkui Sun (ORCID: https://orcid.org/0000-0001-8536-8442)
- Wenxing He (ORCID: https://orcid.org/0009-0001-9298-5075)
- Tenghua Yu (ORCID: https://orcid.org/0000-0001-6346-8573)
- Dongmei Li (ORCID: https://orcid.org/0000-0002-4657-7062)
Institutions
- Jiangxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1675874
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wu Jieping Medical Foundation