A set of serum proteomic biomarkers differentiates celiac children from age and human leukocyte antigen‐matched healthy controls
Patients with CD, compared to age- and HLA-matched healthy controls, show in their sera an increased expression of inflammatory molecules, involved in NF-κB cytokine signaling, cell apoptosis, and crypt proliferation pathways. A set of seven of these proteins can differentiate cases from controls with an accuracy higher than 90%. The implementation of this approach in clinical setting could in future facilitate a noninvasive and individualized approach for CD diagnosis.
Authors
- Riccardo Troncone
- Renata Auricchio (ORCID: https://orcid.org/0000-0001-6958-1251)
- Janneke N. Samsom (ORCID: https://orcid.org/0000-0001-8054-3440)
- Roberta Mandile (ORCID: https://orcid.org/0009-0008-1806-0147)
- Maria Vittoria Barone (ORCID: https://orcid.org/0000-0001-6190-4917)
- Pietro Formisano
- Martina Carpinelli
- Michele Francesco Di Tolla (ORCID: https://orcid.org/0000-0002-1376-3782)
- Rossella De Cegli (ORCID: https://orcid.org/0000-0002-8526-8692)
- Luigi Greco (ORCID: https://orcid.org/0000-0002-9443-5325)
Institutions
- Federico II University Hospital (IT)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Telethon Institute Of Genetics And Medicine (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1002/jpn3.70261
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- HORIZON EUROPE Framework Programme