Genetic and clinical characteristics associated with antidepressant-induced mania in depression patients
AIM was observed in one-fifth of depressive patients of the Han Chinese origin, with female gender and psychiatric comorbidities as significant clinical characteristics. This GWAS of AIM in depressive patients identified potential genetic markers and suggested that a genetic predisposition to bipolar disorder may increase the likelihood of developing AIM, although this association did not reach statistical significance. Future research should aim to increase sample size and further investigate genotype-AIM associations.
Authors
- Po‐Hsiu Kuo (ORCID: https://orcid.org/0000-0003-0365-3587)
- Shiau‐Shian Huang (ORCID: https://orcid.org/0000-0001-8647-1871)
- Chiao-Erh Chang (ORCID: https://orcid.org/0000-0003-3361-5039)
- Shih‐Jen Tsai (ORCID: https://orcid.org/0000-0002-9987-022X)
- Mei-Hsin Su
- Yuning Chen (ORCID: https://orcid.org/0000-0002-6626-9403)
- Ying‐Ting Chao
Institutions
- National Taiwan University (TW)
- Taipei Veterans General Hospital (TW)
- Taichung Veterans General Hospital (TW)
- National Taiwan University Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Comprehensive Psychiatry
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.comppsych.2025.152648
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00