The evolution of cardiac changes after breast cancer adjuvant radiotherapy – A six-year follow-up study

Subclinical deterioration in cardiac function and elevated biomarkers were evident three years after RT and persisted at six years, suggesting permanent cardiac effects. Both radiation dose and AI therapy contributed to these changes. These findings underscore the importance of long-term cardiac monitoring and support the use of sensitive imaging and biomarkers to detect early radiotherapy-induced cardiotoxicity.

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Publication Details

Journal
Clinical and Translational Radiation Oncology
Published
2025-11-20
DOI
https://doi.org/10.1016/j.ctro.2025.101078
Primary Topic
Chemotherapy-induced cardiotoxicity and mitigation
Type
article
Field-Weighted Citation Impact
0.00

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article

The evolution of cardiac changes after breast cancer adjuvant radiotherapy – A six-year follow-up study

Mikko Moisander, Kjell Nikus, Tanja Skyttä, Vesa Virtanen et al.
Clinical and Translational Radiation Oncology
Chemotherapy-induced cardiotoxicity and mitigation
article

The evolution of cardiac changes after breast cancer adjuvant radiotherapy – A six-year follow-up study

Mikko Moisander, Kjell Nikus, Tanja Skyttä, Vesa Virtanen, Pekka Raatikainen, Heini Huhtala, Suvi Tuohinen, Pirkko‐Liisa Kellokumpu‐Lehtinen, Heidi Lähdeaho
article en

Abstract

Subclinical deterioration in cardiac function and elevated biomarkers were evident three years after RT and persisted at six years, suggesting permanent cardiac effects. Both radiation dose and AI therapy contributed to these changes. These findings underscore the importance of long-term cardiac monitoring and support the use of sensitive imaging and biomarkers to detect early radiotherapy-induced cardiotoxicity.

Clinical and Translational Radiation OncologyVol. 56
Tampere University of Applied Sciences (FI), Helsinki University Hospital (FI), Tampere University Hospital (FI), Tampere University (FI)
Suomen Kulttuurirahasto, Servier
Openalex Percentile: Top 48%
Chemotherapy-induced cardiotoxicity and mitigation
DOIOpen Access PDFOpenAlex
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The evolution of cardiac changes after breast cancer adjuvant radiotherapy – A six-year follow-up study — Mikko Moisander, Kjell Nikus, et al. · Clinical and Translational Radiation Oncology (2025) | TGRS Research Map | TGRS