Development and validation of nomograms of outcomes for first-line platinum-based chemotherapy for metastatic triple-negative breast cancer: patient-level analysis of five prospective clinical trials in China
The PFP-TNBC-OS and PFP-TNBC-PFS nomograms provide practical tools to estimate outcomes in mTNBC patients treated with first-line platinum chemotherapy. While C-index values indicated modest discrimination, time-dependent AUCs showed good accuracy at clinically relevant intervals. These models may aid risk stratification, patient counseling, and shared decision-making in chemotherapy-only settings. Future studies are warranted to evaluate their applicability in the evolving era of chemoimmunotherapy.
Authors
- Yifan Chen (ORCID: https://orcid.org/0000-0002-5069-3672)
- Biyun Wang (ORCID: https://orcid.org/0000-0002-7829-1544)
- Yannan Zhao (ORCID: https://orcid.org/0000-0003-1353-8443)
- Zhonghua Tao (ORCID: https://orcid.org/0000-0003-3975-3803)
- Leiping Wang (ORCID: https://orcid.org/0000-0002-0605-1621)
- Jun Cao
- Chengcheng Gong (ORCID: https://orcid.org/0000-0002-5429-0248)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7217-0111)
- Ting Li (ORCID: https://orcid.org/0009-0003-9272-497X)
- Xichun Hu (ORCID: https://orcid.org/0000-0001-5856-830X)
- Mingchuan Zhao
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Therapeutic Advances in Medical Oncology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1177/17588359251395906
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00