Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis
In critically ill patients, escalating doses of noradrenaline correlate with an exponentially rising relative risk of mortality. This dose-dependent pattern reinforces the role of noradrenaline dose as a marker of cardiovascular failure severity.
Authors
- Otávio T. Ranzani (ORCID: https://orcid.org/0000-0002-4677-6862)
- Mervyn Singer (ORCID: https://orcid.org/0000-0002-1042-6350)
- Louis Delamarre (ORCID: https://orcid.org/0000-0002-4051-3834)
- Inès Lakbar (ORCID: https://orcid.org/0000-0003-0049-6248)
- Matti Reinikainen (ORCID: https://orcid.org/0000-0001-6878-3740)
- Steven M. Hollenberg (ORCID: https://orcid.org/0000-0003-1293-8496)
- Suzana Margareth Lobo (ORCID: https://orcid.org/0000-0003-2726-2441)
- Rui Paulo Moreno (ORCID: https://orcid.org/0000-0002-9795-8316)
- Annika Reintam Blaser (ORCID: https://orcid.org/0000-0003-1211-7372)
- Ederlon Rezende
Institutions
- Faculdade de Medicina de São José do Rio Preto (BR)
- Emory University (US)
- University of Beira Interior (PT)
- University of Lucerne (CH)
- University of Eastern Finland (FI)
- Université de Montpellier (FR)
- Hospital de Base (BR)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Hospital de Sant Pau (ES)
- Bury College (GB)
- Kuopio University Hospital (FI)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Hôpital Gui de Chauliac (FR)
- Hôpital Saint Eloi (FR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Hospital do Servidor Público Estadual (BR)
- Hospital de Base (BR)
- University College London (GB)
- University of Tartu (EE)
Publication Details
- Journal
- Critical Care
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1186/s13054-025-05717-9
- Citations
- 2
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.59