(P24) a new era in female sexual health: pilot study on regenerative Gynecology and its impact on sexual function and quality of life

Abstract Background Female sexual dysfunction (FSD) significantly impacts women’s quality of life (QoL). Regenerative gynecological procedures offer potential therapeutic options, yet their effects on female sexual health and quality of sexual life (QoSL) remain understudied. This longitudinal pilot study aimed to comprehensively evaluate the impact of various regenerative gynecological procedures on female sexual health and QoSL. Methods Sixty-four sexually active women (mean age 39.9 years) undergoing regenerative procedures (eg, PRP, HA, fat grafting, stem cells, exosomes, PDRN, and acellular matrices) were enrolled. The validated Female Sexual Quality of Life (SQOL-f) questionnaire and detailed assessments of specific sexual function domains were administered at baseline and 6 months post-intervention. Results Participants commonly presented with vaginal laxity, incontinence, and various sexual difficulties at baseline. Following regenerative procedures, significant improvements were observed in multiple domains of the SQOL-f questionnaire, including sexual selfesteem, desire, arousal, lubrication, orgasm, satisfaction, and overall QoSL. Confidence as a sexual partner, worry about sexual life, avoidance of intercourse, and satisfaction with sexual frequency also improved significantly. However, minimal changes were noted in closeness to partner and communication about sexual matters. Conclusion Regenerative gynecological procedures demonstrate promising potential for enhancing female sexual health and QoL, with significant improvements across multiple domains of sexual function. However, addressing broader relational and psychological aspects may require additional interventions. Further research, including randomized controlled trials, is warranted to validate these findings and establish comprehensive treatment guidelines.