Involved Neck Only Versus Mucosal Radiation Therapy for Head and Neck Squamous Cell Cancer of Unknown Primary (HNSCCUP): A National Retrospective Multicenter Cohort Study
This is the largest series to date of patients with unilateral HNSCCUP treated radically with radiation therapy in the human papillomavirus and FDG PET-CT era. Acceptably low rates of primary site emergence, lower toxicity, and no difference in overall survival when compared with prophylactic MUC radiation therapy suggest that INO radiation therapy in HNSCCUP may be a feasible alternative in contemporary practice.
Authors
- John Hardman (ORCID: https://orcid.org/0000-0002-6591-5119)
- Michael Rowe (ORCID: https://orcid.org/0000-0002-6940-5546)
- Richard P. Kitson
- Karin Purshouse (ORCID: https://orcid.org/0000-0003-0942-6342)
- Wai‐Yan Poon (ORCID: https://orcid.org/0000-0002-4211-3738)
- Zsuzsanna Iyizoba-Ebozue (ORCID: https://orcid.org/0000-0002-9839-4532)
- S Thomas (ORCID: https://orcid.org/0000-0003-2766-9524)
- Mary Denholm (ORCID: https://orcid.org/0000-0001-5875-4487)
- Adam Peters (ORCID: https://orcid.org/0000-0002-8509-2877)
- Sarah Kingdon (ORCID: https://orcid.org/0000-0002-6582-9632)
- Jennifer David Peck (ORCID: https://orcid.org/0000-0003-0024-8818)
- Sarah Walters (ORCID: https://orcid.org/0000-0001-9929-1917)
- Osanmofe Gbenebichie
- Kohgulakuhan Yogalingam (ORCID: https://orcid.org/0000-0001-9780-4862)
- Claire Paterson (ORCID: https://orcid.org/0000-0002-1691-5016)
- Laura C. Kennedy (ORCID: https://orcid.org/0000-0001-8958-7909)
- Adam Muse
- Siona Growcott
- David J. Noble (ORCID: https://orcid.org/0000-0001-6738-2152)
- Robin Prestwich (ORCID: https://orcid.org/0000-0002-7872-2826)
- Mark Baxter (ORCID: https://orcid.org/0000-0002-5773-8650)
- Karen Mactier (ORCID: https://orcid.org/0000-0003-1202-8548)
- Yifei Wang (ORCID: https://orcid.org/0000-0003-2813-1128)
- R. Fernandes (ORCID: https://orcid.org/0000-0003-4823-9873)
- Christina Wilson (ORCID: https://orcid.org/0000-0001-7364-1800)
- Kirsten Laws (ORCID: https://orcid.org/0000-0002-9788-7845)
- C. Hannon
- Kirsty Cavanagh
- Katarzyna Grellier
Institutions
- Beatson West of Scotland Cancer Centre (GB)
- Aberdeen Royal Infirmary (GB)
- Edinburgh Cancer Research (GB)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.11.013
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beatson Cancer Charity
- Cancer Research UK