De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors
Our study presented the de novo design of a two-step drug delivery system targeting Claudin-6 with enhanced anti-tumor efficacy and improved biosafety. These findings highlighted the potential of this approach to enhance the efficacy of tumor-targeting therapies and reduce adverse effects, paving the way for more effective cancer treatments.
Authors
- Baorui Liu (ORCID: https://orcid.org/0000-0002-2539-7732)
- Jiayao Yan
- Zhong Liu (ORCID: https://orcid.org/0000-0002-7130-1017)
- Jingyi Guo (ORCID: https://orcid.org/0000-0003-0215-2895)
- Rutian Li (ORCID: https://orcid.org/0000-0003-4800-6156)
- Lei Lei (ORCID: https://orcid.org/0009-0005-0104-9951)
- Xiaoxiao Yu (ORCID: https://orcid.org/0000-0002-7242-7375)
- Lin Li (ORCID: https://orcid.org/0000-0002-2158-7096)
- Qin Liu (ORCID: https://orcid.org/0009-0002-8922-8927)
- Ying Wang (ORCID: https://orcid.org/0000-0002-8566-875X)
- Xiaotong Chen (ORCID: https://orcid.org/0000-0002-9997-554X)
- Wei Lie Xiao (ORCID: https://orcid.org/0000-0002-8426-9060)
- Tianran Chen (ORCID: https://orcid.org/0009-0006-7100-7930)
- Jie Shao (ORCID: https://orcid.org/0000-0002-4884-462X)
- Yingjie Zhao (ORCID: https://orcid.org/0000-0001-7170-2403)
- Fangcen Liu (ORCID: https://orcid.org/0000-0002-1845-9907)
- Mahru C. An
Institutions
- Zhongda Hospital Southeast University (CN)
- Nanjing Drum Tower Hospital (CN)
- Massachusetts Institute of Technology (US)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1186/s12967-025-07316-2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00