Indian cobra ( <scp> <i>Naja naja</i> </scp> ) venom‐induced neutrophil extracellular trap (NET) formation: The role of cytotoxins and calcium flux
This study identified N. naja venom cytotoxins/cardiotoxins of the 3FTx family as key inducers of NETs. The NET-forming mechanism involves a cytosolic Ca<sup>2+</sup> spike, resulting in cytoskeletal rearrangements, highlighting potential therapeutic targets for mitigating venom-induced pathologies.
Authors
- Kempaiah Kemparaju (ORCID: https://orcid.org/0000-0003-3204-0907)
- Somanathapura K. NaveenKumar (ORCID: https://orcid.org/0000-0002-8991-5041)
- Kumaragurubaran Karthik (ORCID: https://orcid.org/0000-0002-9215-6306)
- Basavarajaiah Swethakumar
- Kunthurumole S. Prashanth
- Rajat Kumar (ORCID: https://orcid.org/0000-0003-2278-4574)
- Gnanesh Kumar BS
- Kesturu S. Girish
Institutions
- Central Food Technological Research Institute (IN)
- University of Mysore (IN)
- Tumkur University (IN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1111/bph.70202
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- University of Mysore
- Science and Engineering Research Board