Sex differences in hemodynamics and outcomes after transcatheter aortic valve replacement
In this international TAVR cohort, women, despite being older, demonstrated better survival than men, with comparable postprocedural hemodynamic outcomes. Severe PPM was associated with increased mortality only in men, likely reflecting underlying comorbidities and low-flow states. After adjustment for confounders, PPM was no longer associated with survival in either sex. These findings underscore the need for strategies accounting for both procedural and patient-specific risks, beyond prosthesis hemodynamics.
Authors
- Nicolas M. Van Mieghem (ORCID: https://orcid.org/0000-0002-2732-1205)
- Marco Barbanti (ORCID: https://orcid.org/0000-0002-4903-5437)
- Markus Pauly (ORCID: https://orcid.org/0000-0002-0976-7190)
- Rik Adrichem (ORCID: https://orcid.org/0000-0002-1001-8840)
- Max M. Meertens (ORCID: https://orcid.org/0000-0002-7746-8723)
- Malte Kelm (ORCID: https://orcid.org/0000-0003-0060-1052)
- Verena Veulemans (ORCID: https://orcid.org/0000-0002-2744-2154)
- Matjaž Bunc (ORCID: https://orcid.org/0000-0001-7269-8944)
- Giuseppe Tarantini (ORCID: https://orcid.org/0000-0002-5055-2917)
- Ute Mons (ORCID: https://orcid.org/0000-0003-1764-6783)
- Helge Möllmann (ORCID: https://orcid.org/0000-0002-6047-0990)
- Philipp Ruile (ORCID: https://orcid.org/0000-0003-3379-5797)
- Clemens Eckel (ORCID: https://orcid.org/0000-0002-8853-8096)
- Tobias Schmidt (ORCID: https://orcid.org/0000-0001-7381-3836)
- Jonathan Curio (ORCID: https://orcid.org/0000-0002-3437-7450)
- Victor Mauri (ORCID: https://orcid.org/0000-0003-2678-3501)
- Tobias Andreas Rheude (ORCID: https://orcid.org/0000-0002-3426-6080)
- Christian Frerker (ORCID: https://orcid.org/0000-0003-0226-0888)
- Tobias Zeus
- Ole De Backer (ORCID: https://orcid.org/0000-0002-9674-0278)
- Rodrigo Estévez‐Loureiro (ORCID: https://orcid.org/0000-0001-5841-5514)
- Stephan Nienaber (ORCID: https://orcid.org/0000-0001-5779-7549)
- Costanza Pellegrini (ORCID: https://orcid.org/0000-0001-5143-8203)
- Max Potratz (ORCID: https://orcid.org/0000-0003-4044-7037)
- Matthias Renker (ORCID: https://orcid.org/0000-0002-4756-5397)
- Jury Schewel (ORCID: https://orcid.org/0000-0003-3621-2892)
- Martin Landt
- Philipp von Stein (ORCID: https://orcid.org/0000-0003-4548-3897)
- Ignacio Jesus Amat-Santos (ORCID: https://orcid.org/0000-0002-2311-4129)
- Niklas Schofer (ORCID: https://orcid.org/0000-0001-5190-813X)
- Sascha Macherey‐Meyer (ORCID: https://orcid.org/0000-0002-7080-6611)
- Stephan Baldus (ORCID: https://orcid.org/0000-0001-8259-1737)
- Efstratios I. Charitos (ORCID: https://orcid.org/0000-0003-0284-8200)
- Baravan Al‐Kassou (ORCID: https://orcid.org/0000-0003-2967-6613)
- Jérémy Wrobel (ORCID: https://orcid.org/0000-0001-5165-2138)
- Corrado Tamburino (ORCID: https://orcid.org/0000-0002-4940-9742)
- Won‐Keun Kim (ORCID: https://orcid.org/0000-0003-3178-8569)
- Sabine Bleiziffer (ORCID: https://orcid.org/0000-0001-9669-7372)
- Hendrik Wienemann (ORCID: https://orcid.org/0000-0001-5810-2868)
- Henning Guthoff (ORCID: https://orcid.org/0000-0002-0979-1190)
- Sebastian Ludwig (ORCID: https://orcid.org/0000-0002-5752-4951)
- Dabit Arzamendi (ORCID: https://orcid.org/0000-0001-7543-5867)
- Stefan Toggweiler (ORCID: https://orcid.org/0000-0002-7860-0298)
- Salome Hecht
- Valerie Lohner (ORCID: https://orcid.org/0000-0001-5589-9701)
- Luis Nombela-Franco y (ORCID: https://orcid.org/0000-0003-3438-8907)
- Manuel Hein (ORCID: https://orcid.org/0000-0003-0430-7184)
- Michael Joner (ORCID: https://orcid.org/0000-0002-2971-8310)
- Ines Richter
- Matti Adam (ORCID: https://orcid.org/0000-0002-6990-8135)
- Tanja K. Rudolph (ORCID: https://orcid.org/0000-0001-8839-7476)
- Guy Witberg (ORCID: https://orcid.org/0000-0003-2110-0484)
- Maria Thurow (ORCID: https://orcid.org/0000-0002-8710-6857)
- Jasmin Shamekhi (ORCID: https://orcid.org/0000-0002-5724-9814)
- Samuel Lee (ORCID: https://orcid.org/0000-0001-6768-7079)
- Ahmed Abdelhafez (ORCID: https://orcid.org/0000-0002-1019-0536)
- Ariel Finkelstein
- Darren Mylotte
- Georg Nickenig (ORCID: https://orcid.org/0000-0003-2944-6033)
- Ina von der Heide
- Luca Branca
- Andreas Rück
- Holger Thiele
- Mohamed Abdel-Waha
Institutions
- Tel Aviv University (IL)
- University of Cologne (DE)
- Justus-Liebig-Universität Gießen (DE)
- University Hospital Bonn (DE)
- Rabin Medical Center (IL)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- Erasmus MC (NL)
- Ford (Germany) (DE)
- Düsseldorf University Hospital (DE)
- Helios Hospital Siegburg (DE)
- Mitsubishi Corporation (Germany) (DE)
- Leipzig Heart Institute (DE)
- Luzerner Kantonsspital (CH)
- Asklepios Klinik St. Georg (DE)
- German Centre for Cardiovascular Research (DE)
- Marienkrankenhaus Hamburg (DE)
- Kerckhoff Klinik (DE)
- Cardiovascular Research Foundation (US)
- St.-Johannes-Hospital Dortmund (DE)
- Deutsches Herzzentrum München (DE)
- Segeberger Kliniken (DE)
- University Hospital Cologne (DE)
- Asklepios (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Clinical Research in Cardiology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1007/s00392-025-02794-2
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Deutsche Forschungsgemeinschaft
- Universität zu Köln