Epigenome-wide profiling of trisomy 18 specific DNA methylation signatures in first-trimester chorionic villi
To our knowledge, this is the first comprehensive MC-seq-based analysis of T18-specific DNA methylation patterns in first-trimester chorionic villi. These findings suggest that DNA methylation changes may represent downstream consequences of chromosomal imbalance in T18 and provide a foundation for future investigations into its pathophysiology and the development of epigenetic biomarkers for early non-invasive detection.
Authors
- Ji Hyae Lim (ORCID: https://orcid.org/0000-0002-1105-7235)
- You Jung Han (ORCID: https://orcid.org/0000-0003-4087-9198)
- Sang Hee Jung (ORCID: https://orcid.org/0000-0001-8769-0646)
- Hyun Mee Ryu (ORCID: https://orcid.org/0000-0002-0710-2582)
- Yong Jun Choi (ORCID: https://orcid.org/0000-0003-3960-8470)
- Yang Su (ORCID: https://orcid.org/0000-0002-7042-0524)
- Ji Hyon Jang (ORCID: https://orcid.org/0000-0001-7098-3768)
- Young Ran Kim (ORCID: https://orcid.org/0000-0001-8431-7563)
- Jin‐Woo Kim (ORCID: https://orcid.org/0000-0002-1672-5730)
- Hyun Jung Lee
- Nari Kim (ORCID: https://orcid.org/0000-0002-5297-6385)
- Ju Yeon Kim (ORCID: https://orcid.org/0000-0002-4259-667X)
Institutions
- CHA University Bundang Medical Center (KR)
- CHA University (KR)
- CHA University Gangnam Medical Center (KR)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s13148-025-02018-4
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Health Industry Development Institute