Non-invasive temporal interference stimulation of the hippocampus suppresses epileptic biomarkers in patients with Epilepsy: biophysical differences between kilohertz and amplitude modulated stimulation
Our findings underscore the therapeutic potential of TI as a non-invasive brain stimulation modality for epilepsy, offering significant suppression of epileptic biomarkers through subthreshold modulation of the epileptogenic zone. Furthermore, this study highlights distinct biophysical differences between kilohertz-frequency stimulation and focal amplitude-modulated stimulation, supporting TI's unique utility in neuromodulation research.
Authors
- Florian Missey (ORCID: https://orcid.org/0000-0002-8386-0377)
- Vít Všianský (ORCID: https://orcid.org/0000-0003-0518-8914)
- Martin Pail (ORCID: https://orcid.org/0000-0003-2059-4822)
- Antonino M. Cassarà (ORCID: https://orcid.org/0000-0003-3375-7440)
- Jan Trajlínek
- Adam S. Dickey (ORCID: https://orcid.org/0000-0003-4710-1290)
- Stanislas Lagarde (ORCID: https://orcid.org/0000-0003-2916-1302)
- Rosanna Migliore (ORCID: https://orcid.org/0000-0001-9034-7849)
- Daniel L. Drane (ORCID: https://orcid.org/0000-0001-8747-672X)
- Viktor Jirsa (ORCID: https://orcid.org/0000-0002-8251-8860)
- Evan Brady
- Emma Acerbo (ORCID: https://orcid.org/0000-0002-9477-4845)
- Robert A. Gross (ORCID: https://orcid.org/0000-0003-4258-3913)
- Niels Kuster (ORCID: https://orcid.org/0000-0002-5827-3728)
- Dániel Fabó (ORCID: https://orcid.org/0000-0001-5141-5351)
- Nigel P. Pedersen (ORCID: https://orcid.org/0000-0002-8494-0635)
- Mariane de Araújo e Silva
- Irena Doležalová (ORCID: https://orcid.org/0000-0002-3166-4817)
- Adam Williamson
- Michele Migliore
- Esra Neufeld (ORCID: https://orcid.org/0000-0001-5528-6147)
- Milan Brázdil (ORCID: https://orcid.org/0000-0001-7979-2343)
- Johanna Petra Szabó (ORCID: https://orcid.org/0000-0001-7690-9171)
- Raul Castillo Astorga
- Ondřej Studnička
- Fariba Karimi (ORCID: https://orcid.org/0000-0002-2209-7590)
- Claire-Anne Gutekunst
- Romain Carron
- Fabrice Bartolomei
- Claudia Lubrano
Institutions
- Semmelweis University (HU)
- Emory University (US)
- Inserm (FR)
- SUNY Downstate Health Sciences University (US)
- Masaryk University (CZ)
- Aix-Marseille Université (FR)
- Johnson University (US)
- Foundation for Research on Information Technologies in Society (CH)
- University Hospital Brno (CZ)
- Institut de Neurosciences des Systèmes (FR)
- International Clinical Research Center, St. Anne's University Hospital Brno (CZ)
- St. Anne's University Hospital Brno (CZ)
- National Research Council (IT)
- University of California, Davis (US)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.brs.2025.11.008
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17