5-Methoxytryptophan attenuates hypobaric hypoxia induced acute lung injury by alleviating lipid peroxidation via targeting peroxiredoxin 6
5-MTP is a predictive biomarker of hypoxic maladaptation. The restoration of 5-MTP attenuated ALI by inhibiting lipoperoxidation and protecting endothelial barrier via directly interaction with Ser32 site of Prdx6 to prevent its lysosomal degradation.
Authors
- Ding‐Yuan Tian (ORCID: https://orcid.org/0000-0002-2542-5211)
- Hongjun Yin (ORCID: https://orcid.org/0000-0002-6249-2261)
- Ziyang Wang (ORCID: https://orcid.org/0000-0002-0368-9590)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-2700-6739)
- Qingyuan Yang (ORCID: https://orcid.org/0000-0001-8808-1113)
- Yujie Li (ORCID: https://orcid.org/0000-0001-6743-4039)
- Zhongfang Deng
- Pan Zheng (ORCID: https://orcid.org/0000-0003-2598-3544)
- Fang Deng (ORCID: https://orcid.org/0000-0002-7927-5394)
- Qi Huang (ORCID: https://orcid.org/0000-0002-1600-1169)
- Xiaoyue Lai
- Xiaoqin Wan
- Chun Liu (ORCID: https://orcid.org/0000-0002-7975-9583)
- Ming Chen
- Zhihui Zhang (ORCID: https://orcid.org/0000-0003-1876-9312)
- Gang Xu (ORCID: https://orcid.org/0000-0003-0687-8108)
- Xinyu Bao (ORCID: https://orcid.org/0009-0008-8230-349X)
- Hongmei Xia (ORCID: https://orcid.org/0000-0002-1829-564X)
- Xiaoshi Cai
- Yan Tan
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1016/j.redox.2025.103922
- Citations
- 1
- Primary Topic
- Redox biology and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81