Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implications

We included 81 studies (n = 2542; rodents=2510; monkeys=26), resulting in 226 meta-analyses. Both typical and atypical antipsychotics modulated PSD molecules albeit with different degree due to the drug receptor profile, dose, specific protein detected, brain region, and administration regimen. Haloperidol, amisulpride, and aripiprazole significantly increased PSD protein expression in the striatum. Acute olanzapine increased PSD molecules levels in striatal regions, reducing Arc expression in frontal cortex (SMD [95%CIs]=-2.15 [-2.7;-1.61], p < 0.0001); chronic treatment had opposite effects. Clozapine increased Homer1a levels in dorsal (1.13 [0.41;1.86], p = 0.002) and ventral striatum (1.48 [0.72;2.24], p = 0.0001), and cingulate cortex (2.12 [1.12;3.12], p < 0.0001), as well as increased NMDAR subunits levels in frontal cortex.

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Publication Details

Journal
Molecular Psychiatry
Published
2025-11-19
DOI
https://doi.org/10.1038/s41380-025-03351-z
Citations
1
Primary Topic
Neurotransmitter Receptor Influence on Behavior
Type
article
Field-Weighted Citation Impact
0.91
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article

Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implications

Andrea de Bartolomeis, Michele Fornaro, Giuseppe De Simone, Licia Vellucci et al.
1 citations
Molecular Psychiatry
Neurotransmitter Receptor Influence on Behavior
0.91
article

Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implications

Andrea de Bartolomeis, Michele Fornaro, Giuseppe De Simone, Licia Vellucci, Giovanna Fico, Felice Iasevoli, Mariateresa Ciccarelli, Eduard Vieta, Vincenzo Oliva, Michele De Prisco, Benedetta Mazza
article en
1 citations

Abstract

We included 81 studies (n = 2542; rodents=2510; monkeys=26), resulting in 226 meta-analyses. Both typical and atypical antipsychotics modulated PSD molecules albeit with different degree due to the drug receptor profile, dose, specific protein detected, brain region, and administration regimen. Haloperidol, amisulpride, and aripiprazole significantly increased PSD protein expression in the striatum. Acute olanzapine increased PSD molecules levels in striatal regions, reducing Arc expression in frontal cortex (SMD [95%CIs]=-2.15 [-2.7;-1.61], p < 0.0001); chronic treatment had opposite effects. Clozapine increased Homer1a levels in dorsal (1.13 [0.41;1.86], p = 0.002) and ventral striatum (1.48 [0.72;2.24], p = 0.0001), and cingulate cortex (2.12 [1.12;3.12], p < 0.0001), as well as increased NMDAR subunits levels in frontal cortex.

Molecular PsychiatryVol. 31(2)
Instituto de Salud Carlos III (ES), Centro de Investigación Biomédica en Red de Salud Mental (ES), Departament de Salut (ES), Hospital Clínic de Barcelona (ES), Federico II University Hospital (IT), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), University of Naples Federico II (IT)
Openalex Percentile: Top 20%
Neurotransmitter Receptor Influence on Behavior
0.91
DOIOpen Access PDFOpenAlex
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