Governmental Questionnaire Survey on Adolescent and Young Adults’ Views on the Clinical Application of Xenotransplantation

This survey explored the ethical, legal, and social implications (ELSI) of xenotransplantation in adolescents and young adults. A web-based questionnaire targeting individuals aged 12-30 was conducted via a Japanese government platform. Results from 113 responses revealed generally positive attitudes toward xenotransplantation, particularly among males, and also highlighted concerns about infection, identity, and animal ethics. Most respondents conditionally accepted xenotransplantation, emphasizing informed consent and societal awareness. Xenotransplantation was ranked lowest in treatment priority compared to regenerative medicine and human organ transplantation. The survey captured respondents' feelings about themselves or friends receiving xenotransplants and highlighted issues to address before clinical use in Japan. Findings were presented at a national expert committee meeting, emphasizing the importance of including adolescent and young adults' perspectives in research and review processes. As Japan considers xenotransplantation research under regulation, this survey offers global insights to support ELSI-aligned development.