DHCR7: from sterol biosynthesis to oncogenic role in colorectal cancer
DHCR7 regulates the progression of CRC both <i>in vitro</i> and <i>in vivo</i> through the PI3K/AKT/mTOR signaling axis and affects the cholesterol levels in CRC.
Authors
- Bin Wei (ORCID: https://orcid.org/0000-0002-2862-2907)
- Mingxu Da (ORCID: https://orcid.org/0000-0001-9181-6088)
- Jia‐Yi Wang (ORCID: https://orcid.org/0000-0002-9106-3351)
- Chuan Zhou (ORCID: https://orcid.org/0009-0000-3693-265X)
- Wenbo Zhang (ORCID: https://orcid.org/0000-0003-4682-354X)
- Chao Wang (ORCID: https://orcid.org/0000-0002-0812-904X)
- Yunfeng Zhang (ORCID: https://orcid.org/0000-0003-1078-0752)
- Han He (ORCID: https://orcid.org/0000-0001-6206-1683)
- Minghui Pang (ORCID: https://orcid.org/0000-0002-2661-7848)
Institutions
- University of Electronic Science and Technology of China (CN)
- Shaanxi Provincial People's Hospital (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
- Chinese Institute for Brain Research (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-11-20
- DOI
- https://doi.org/10.7717/peerj.20323
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00