A Silver (I) Complex-Loaded Lipid Nanoemulsion: A New Approach Against Candida albicans Biofilms

Introduction: The increasing prevalence of fungal infections, particularly those caused by Candida albicans, presents a significant clinical challenge due to the emergence of drug-resistant strains. Silver (I) coordination complexes show promise as antifungal agents; however, their poor water solubility limits clinical application. Methods: In this study, we developed and characterized a lipid nanoemulsion (Ag-LN) to enhance the delivery and activity of a silver (I) complex. Results: The formulation exhibited nanoscale size, spherical morphology, and stability for up to 60 days. Ag-LN showed potent antifungal effects, preventing biofilm formation and eradicating mature biofilms. Importantly, nanoencapsulation preserved antifungal activity while reducing mutagenic potential and acute toxicity compared with the free compound. Conclusions: These findings support Ag-LN as a promising antifungal platform for future preclinical studies.

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Publication Details

Journal
Drugs and Drug Candidates
Published
2025-11-15
DOI
https://doi.org/10.3390/ddc4040052
Primary Topic
Antimicrobial agents and applications
Type
article
Field-Weighted Citation Impact
0.00

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article

A Silver (I) Complex-Loaded Lipid Nanoemulsion: A New Approach Against Candida albicans Biofilms

Giovanna Capaldi Fortunato, Adelino V.G. Netto, Flávia Aparecida Resende, Leonardo Delello Di Filippo et al.
Drugs and Drug Candidates
Antimicrobial agents and applications
article

A Silver (I) Complex-Loaded Lipid Nanoemulsion: A New Approach Against Candida albicans Biofilms

Giovanna Capaldi Fortunato, Adelino V.G. Netto, Flávia Aparecida Resende, Leonardo Delello Di Filippo, Gabriel Davi Marena, Marlus Chorilli, Tamara Renata Machado Ribeiro, Cristiano G. Moreira, Taís Maria Bauab, Débora E.S. Silva
article en

Abstract

Introduction: The increasing prevalence of fungal infections, particularly those caused by Candida albicans, presents a significant clinical challenge due to the emergence of drug-resistant strains. Silver (I) coordination complexes show promise as antifungal agents; however, their poor water solubility limits clinical application. Methods: In this study, we developed and characterized a lipid nanoemulsion (Ag-LN) to enhance the delivery and activity of a silver (I) complex. Results: The formulation exhibited nanoscale size, spherical morphology, and stability for up to 60 days. Ag-LN showed potent antifungal effects, preventing biofilm formation and eradicating mature biofilms. Importantly, nanoencapsulation preserved antifungal activity while reducing mutagenic potential and acute toxicity compared with the free compound. Conclusions: These findings support Ag-LN as a promising antifungal platform for future preclinical studies.

Drugs and Drug CandidatesVol. 4(4)
Louisiana State University (US), Instituto Butantan (BR), Centro Universitário de Araraquara (BR), Universidade Estadual Paulista (Unesp) (BR)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Universidade Estadual Paulista
Openalex Percentile: Top 73%
Antimicrobial agents and applications
DOIOpen Access PDFOpenAlex
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