Nonmuscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling
A nonmuscle actinin (ACTN4) populates the cardiac Z-disc. ACTN4 regulates sarcomeric architecture in CMs. ACTN4 influences fractional shortening at the cell level and contractility at the tissue level. Changes in ventricular ACTN4 levels are associated with remodeling and may influence clinical outcomes related to heart failure.
Authors
- Alaina H. Willet (ORCID: https://orcid.org/0000-0002-0163-4772)
- Yu Wang (ORCID: https://orcid.org/0000-0002-2819-4551)
- Abigail C. Neininger (ORCID: https://orcid.org/0000-0001-5104-4407)
- James B. Hayes (ORCID: https://orcid.org/0000-0002-9321-212X)
- Matthew J. Tyska (ORCID: https://orcid.org/0000-0003-2238-6189)
- Zachary Sanchez (ORCID: https://orcid.org/0000-0001-9075-1577)
- Cynthia A. Reinhart‐King (ORCID: https://orcid.org/0000-0001-6959-3914)
- W. David Merryman (ORCID: https://orcid.org/0000-0001-9662-1503)
- Nilay Taneja (ORCID: https://orcid.org/0000-0002-9046-0953)
- Quinn S. Wells (ORCID: https://orcid.org/0000-0003-3899-0313)
- Kyra Smart (ORCID: https://orcid.org/0000-0002-5556-3922)
- Dharmendra Choudhary (ORCID: https://orcid.org/0000-0002-8657-6005)
- Dylan Ritter (ORCID: https://orcid.org/0000-0002-8704-908X)
- Dylan T. Burnette (ORCID: https://orcid.org/0000-0002-2571-7038)
- Ela W. Knapik (ORCID: https://orcid.org/0000-0002-2977-3619)
- Leah Caplan (ORCID: https://orcid.org/0000-0002-6594-1608)
- Erdem D. Tabdanov (ORCID: https://orcid.org/0000-0003-2673-112X)
- Qi Liu (ORCID: https://orcid.org/0000-0001-8892-7078)
- Xiao Liu (ORCID: https://orcid.org/0000-0003-0654-7333)
- David Armstrong (ORCID: https://orcid.org/0000-0003-3198-7277)
Institutions
- Pennsylvania State University (US)
- Vanderbilt University (US)
- Penn State Milton S. Hershey Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1161/circresaha.125.326412
- Citations
- 2
- Primary Topic
- Genetics and Physical Performance
- Type
- article
- Field-Weighted Citation Impact
- 3.63