Linalool as a potential agent against Toxoplasma gondii: an in vitro study

The flow cytometry results revealed a dose-dependent anti-Toxoplasma activity for linalool, with 18.37%, 36.77%, 38.75%, 47.57%, and 50.63% mortality rates at the concentrations of 37.5, 75, 150, 300, and 600 µg/mL, respectively. The mortality rate at the concentration of 1200 µg/mL (74.44%) was slightly higher than that of the positive control group (67.87%). Our findings provide primary evidence for the extracellular potential of linalool against T. gondii tachyzoites. This study provides a rationale for further research to evaluate linalool's intracellular and in vivo efficacy and safety.