FGF21-engineered ADSCs promote diabetic wound healing by mitigating ferroptosis and oxidative stress via the SIRT1/NRF2/GPX4 signaling pathway
Our study establishes ADSC<sup>FGF21</sup> as a multimodal therapy for diabetic wounds, synergizing stem cell-mediated tissue repair with FGF21's metabolic regulation. By activating the SIRT1/NRF2/GPX4 axis, ADSC<sup>FGF21</sup> restores redox homeostasis and blocks ferroptosis. These findings provide a promising strategy for chronic wound management.
Authors
- Qianqian Hao (ORCID: https://orcid.org/0000-0003-1327-0328)
- Hanli Wang (ORCID: https://orcid.org/0000-0002-9999-4871)
- Yutao Li (ORCID: https://orcid.org/0000-0001-9158-9946)
- Zhen Liang (ORCID: https://orcid.org/0009-0004-5737-1037)
- Na Wang (ORCID: https://orcid.org/0000-0001-9552-0524)
- Yu Zhou (ORCID: https://orcid.org/0000-0001-6839-5326)
- Zhaoxiang Zhang (ORCID: https://orcid.org/0000-0002-1469-1469)
- Xiaoling Xu (ORCID: https://orcid.org/0000-0003-0312-6613)
- Guanghui Wei (ORCID: https://orcid.org/0000-0002-7822-8684)
- Ziyu Wu
- Yizhi Peng
- Baoqiang Song
- Yanan Gu
Institutions
- Army Medical University (CN)
- Xiyuan Hospital (CN)
- Southwest Hospital (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s13287-025-04758-9
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China
- Fourth Military Medical University
- Key Research and Development Projects of Shaanxi Province