Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing
NC exerts anti-CRC effects by downregulating BUB1, disrupting the RAD21-BUB1 axis, and alleviating BUB1-mediated immune suppression.
Authors
- Rong‐Quan He (ORCID: https://orcid.org/0000-0002-7752-2080)
- Kai Xiong (ORCID: https://orcid.org/0000-0002-8170-0273)
- Ke-Jun Wu (ORCID: https://orcid.org/0009-0007-9017-6382)
- Xiao-Jue Huang
- Limin Liu (ORCID: https://orcid.org/0000-0003-2527-7201)
- Gang Chen (ORCID: https://orcid.org/0000-0002-8105-2384)
- Hui Li (ORCID: https://orcid.org/0000-0003-4759-1779)
- Jincheng Li (ORCID: https://orcid.org/0000-0002-8363-3916)
- Wei Zhang
- L. Mo
- J. C. Ling
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Guangxi University of Chinese Medicine (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s12876-025-04423-8
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangxi Medical University
- Division of Graduate Education