Course of joint range of motion in children with spinal muscular atrophy receiving disease-modifying treatment
The course of joint mobility in children with SMA, who started treatment with DMT in the first 18 months of life, is characterised by a decline in knee extension and a stable range of motion of wrist and elbow joints. We stress the importance of monitoring knee extension range of motion at least every 6 months and adopting a proactive approach to maintain full knee extension for optimal lifelong mobility.
Authors
- Bart Bartels (ORCID: https://orcid.org/0000-0002-5801-6692)
- Anita Beelen (ORCID: https://orcid.org/0000-0002-1269-0710)
- Ruben P. A. van Eijk (ORCID: https://orcid.org/0000-0002-7132-5967)
- Jan Willem Gorter (ORCID: https://orcid.org/0000-0002-3012-2119)
- Irene L B Oude Lansink (ORCID: https://orcid.org/0000-0003-4381-6176)
- W. Ludo van der Pol
- D. R. vd Woude
- P. J. Scheiberlich
Institutions
- University Medical Center Utrecht (NL)
- Cancer Genomics Centre (NL)
- De Hoogstraat Revalidatie (NL)
- Wilhelmina Children's Hospital (NL)
- McMaster University (CA)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s13023-025-04109-0
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stichting Spieren voor Spieren