WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia
WTAP suppresses ferroptosis in PE by enhancing YTHDF2-dependent m<sup>6</sup>A methylation and degradation of NCOA4. Disruption of this pathway exacerbates oxidative stress, trophoblast dysfunction, and adverse pregnancy outcomes.
Authors
- Lin Xu (ORCID: https://orcid.org/0000-0001-7750-8011)
- Chunling Ma (ORCID: https://orcid.org/0000-0002-5769-6163)
- Can Li (ORCID: https://orcid.org/0000-0002-8420-120X)
- Chao Li (ORCID: https://orcid.org/0000-0001-7892-5538)
- Zhiyuan Li (ORCID: https://orcid.org/0000-0002-4343-9748)
- Yan Li (ORCID: https://orcid.org/0000-0002-0366-2048)
- Ning Zhang (ORCID: https://orcid.org/0000-0003-2775-1755)
- Shuping Zhao (ORCID: https://orcid.org/0000-0001-6081-934X)
- Qingqing Lv (ORCID: https://orcid.org/0000-0003-1764-6038)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Women and Children's Hospital (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s13148-025-02004-w
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00