Elevated triglyceride-glucose index and risk of thymoma-associated myasthenia gravis: a prospective analysis from the UK Biobank
Elevated TyG index and TG/HDL-C ratio were independently associated with higher thymoma-associated MG risk in this large prospective cohort, with evidence of non-linear relationships and BMI-related heterogeneity. These findings provide novel epidemiologic evidence linking metabolic markers of insulin resistance with thymoma-associated MG, but clinical translation requires further validation.
Authors
- Rusong Yang (ORCID: https://orcid.org/0000-0001-9790-0483)
- Jingwei Shi (ORCID: https://orcid.org/0000-0002-5635-7565)
- Mingjun Wei
- Zhengcheng Liu (ORCID: https://orcid.org/0000-0002-4472-4807)
- Wuji Zhang (ORCID: https://orcid.org/0000-0001-7460-4956)
- Kangle Zhu (ORCID: https://orcid.org/0000-0002-8829-0545)
- Yi‐Chang Zhao (ORCID: https://orcid.org/0000-0002-9651-4457)
- Yao Zhang
- Zhuo Liu
- Jingwei Zhao (ORCID: https://orcid.org/0009-0004-8653-7948)
- Chu Zhou (ORCID: https://orcid.org/0000-0003-3918-556X)
- Zhixiang Shen
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s12933-025-02984-2
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing Drum Tower Hospital