The epidermal growth factor receptor regulates YAP signalling and promotes diabetic retinal fibrosis by modulating the degradation of SAV1
The results of this study demonstrate that EGFR blocks the Hippo pathway by degrading SAV1 in Müller cells. Targeting EGFR effectively mitigated retinal fibrosis in diabetic mice, highlighting its therapeutic potential.
Authors
- Chen Ke-xi (ORCID: https://orcid.org/0000-0002-9552-0767)
- Xiaopei Zhang (ORCID: https://orcid.org/0000-0001-6134-5086)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-8588-2409)
- Ying Wang (ORCID: https://orcid.org/0000-0002-2571-9367)
Institutions
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s12967-025-07357-7
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City