Normative Data for the Montreal Cognitive Assessment (MoCA) in Mexican Adults: A Regression-Based Approach

<b>Background/Objectives:</b> The Montreal Cognitive Assessment (MoCA) is a widely used cognitive screening tool designed to detect cognitive impairment. However, evidence indicates that the original cut-off score of 26 and the one-point correction for low education may not be appropriate across diverse populations. In Latin America, and particularly in Mexico, existing validation studies are scarce and limited by small sample sizes. The objective of this study was to examine the effects of age and education on MoCA performance in Mexican adults and to develop regression-based normative data for more accurate interpretation. <b>Methods:</b> MoCA performance of 2546 cognitively healthy participants aged 18-99 years from two public health institutions in Mexico City was analyzed. Inclusion criteria required preserved cognition, functionality, independence, and absence of conditions directly affecting brain health. The Spanish version 8.1 of the MoCA was administered. Age-adjusted normative values were obtained. Then, regression analyses were applied to generate age- and education-adjusted norms. <b>Results:</b> MoCA total scores correlated negatively with age and positively with education, while sex showed no significant effect. Regression-based norms revealed that identical raw total scores have different normative interpretations depending on age and education. <b>Conclusions:</b> This study provides the first regression-based MoCA norms for Mexican adults, demonstrating that both age and education exert a substantial influence on test performance. These norms enable a more precise, culturally sensitive interpretation than fixed cut-off scores and reduce the risk of misclassification in clinical and research settings.